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Titel
Methanol regulated yeast promoters: production vehicles and toolbox for synthetic biology
VerfasserGasser, Brigitte ; Steiger, Matthias G. ; Mattanovich, Diethard
Erschienen in
Microbial Cell Factories, 2015, Jg. 14,
ErschienenBioMed Central (BMC), 2015
SpracheEnglisch
DokumenttypAufsatz in einer Zeitschrift
Schlagwörter (EN)Pichia pastoris / Komagataella / Promoter / Induction / Synthetic biology / Protein production
ISSN1475-2859
URNurn:nbn:at:at-ubbw:3-819 Persistent Identifier (URN)
DOIdoi:10.1186/s12934-015-0387-1 
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Methanol regulated yeast promoters: production vehicles and toolbox for synthetic biology [0.97 mb]
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Zusammenfassung (Englisch)

Promoters are indispensable elements of a standardized parts collection for synthetic biology. Regulated promoters of a wide variety of well-defined induction ratios and expression strengths are highly interesting for many applications. Exemplarily, we discuss the application of published genome scale transcriptomics data for the primary selection of methanol inducible promoters of the yeast Pichia pastoris (Komagataella sp.). Such a promoter collection can serve as an excellent toolbox for cell and metabolic engineering, and for gene expression to produce heterologous proteins.