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Titel
Genome-wide association study for birth weight in Nellore cattle points to previously described orthologous genes affecting human and bovine height
VerfasserUtsunomiya, Yuri T. ; do Carmo, Adriana S. ; Carvalheiro, Roberto ; Neves, Haroldo H. R. ; Matos, Márcia C. ; Zavarez, Ludmilla B. ; Pérez OBrien, Ana M. ; Sölkner, Johann ; McEwan, John C. ; Cole, John B. ; Van Tassell, Curtis P. ; Schenkel, Flávio S. ; da Silva, Marcos V. G. B. ; Porto Neto, Laercio R. ; Sonstegard, Tad S. ; Garcia, José F.
Erschienen in
BMC Genetics, 2013, Jg. 14, 52 S.
ErschienenBioMed Central (BMC), 2013
SpracheEnglisch
DokumenttypAufsatz in einer Zeitschrift
Schlagwörter (EN)GWAS / Birth weight / Bos primigenius indicus / Nellore cattle / Stature
ISSN1471-2156
URNurn:nbn:at:at-ubbw:3-581 Persistent Identifier (URN)
DOIdoi:10.1186/1471-2156-14-52 
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 Das Werk ist frei verfügbar
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Genome-wide association study for birth weight in Nellore cattle points to previously described orthologous genes affecting human and bovine height [0.61 mb]
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Zusammenfassung (Englisch)

Background:

Birth weight (BW) is an economically important trait in beef cattle, and is associated with growth- and stature-related traits and calving difficulty. One region of the cattle genome, located on Bos primigenius taurus chromosome 14 (BTA14), has been previously shown to be associated with stature by multiple independent studies, and contains orthologous genes affecting human height. A genome-wide association study (GWAS) for BW in Brazilian Nellore cattle (Bos primigenius indicus) was performed using estimated breeding values (EBVs) of 654 progeny-tested bulls genotyped for over 777,000 single nucleotide polymorphisms (SNPs).

Results:

The most significant SNP (rs133012258, PGC = 1.34 10-9), located at BTA14:25376827, explained 4.62% of the variance in BW EBVs. The surrounding 1 Mb region presented high identity with human, pig and mouse autosomes 8, 4 and 4, respectively, and contains the orthologous height genes PLAG1, CHCHD7, MOS, RPS20, LYN, RDHE2 (SDR16C5) and PENK. The region also overlapped 28 quantitative trait loci (QTLs) previously reported in literature by linkage mapping studies in cattle, including QTLs for birth weight, mature height, carcass weight, stature, pre-weaning average daily gain, calving ease, and gestation length.

Conclusions:

This study presents the first GWAS applying a high-density SNP panel to identify putative chromosome regions affecting birth weight in Nellore cattle. These results suggest that the QTLs on BTA14 associated with body size in taurine cattle (Bos primigenius taurus) also affect birth weight and size in zebu cattle (Bos primigenius indicus).