Wood-Plastic-Composites (WPC) are mainly produced with twin-screw extruders, and they usually have degassing capability to get rid of volatile compounds or water vapor. Studies are suggesting that single-screw extruders could be an affordable alternative to produce WPCs, however, they are lacking the possibility of degassing. The concrete technological implementation is missing so far. In this work, the process parameters granulate water content, extruder screw rotation speed, as well as the drying behavior with respect to the single-screw extrusion process were investigated. A polyvinyl-chloride (PVC) - wood flour (50:50) granulate was dried in the Wittman Drymax Aton FS 120 dryer, and extruded on the single-screw extruder. A full-factorial experimental design was chosen to quantify main effects as well as interactions. It was found that energy-efficient and material-friendly drying of granules with PVC at 80C is possible. A gravimetric-thermal anaylsis of the granulate water content delivered significant time-savings. Optimal single-screw-extrusion conditions were found at zero granulate-moisture content, and with a extruder screw-speed of 10rpm.