Lowland paddy rice in Laos is the main crop grown during the rainy season. Climate change is considered as one of the main environmental problems of the current century and it affects directly crop growing conditions such as for rice. This study focus on two objectives which are 1) to estimate the impacts of climate change on rice production in a rice growing region of Savannakhet province and 2) to explore adaption options of local farmers to climate change. To assess the rice yield potential under climate change conditions, the DSSAT CERES-Rice model was applied under three General Circulation Models (GCMs) such as CSMK3, HadCM3 and HadGEM with high and low climate sensitivity, respectively. The resulting six climate change scenarios were the base for the generated daily weather data input for the rice yield simulation of the 21st century (2001 to 2100). Three periods out of these 100 years were finally selected for comparison of the results (2001 to 2030, 2030 to 2065, and 2070 to 2100). The results show that rice yield (of the same selected cultivar) under all six climate change scenarios will increase between +6.8% and +12.8% compared with observation years (1995 to 2009), mainly determined by increasing temperatures from currently sub-optimum level for the simulated cultivar TDK 1. However, if comparison between the three simulated periods, the second period (2035 to 2065) will reach the highest yields and in the third period (2070 to 2100) yields will not further increase. According to the results the rice growing period of the same cultivar will be shortened by approximately 5 to 14 days to between 134 and 143 days in average by the end of the 21st century. Adaptation in rice farming practices may include cultivar change, soil preparing, sowing and transplanting date, weeding, timing and amount of fertilization. Farm technologies and cultivar breeding supporting local rice farming will be further challenges beyond the farm level to ensure or further increase rice production for future climate change conditions.