A capture step for direct capture of recombinant antibodies from clarified culture supernatant was developed. This method is a combination of CaCl2 and polyethylene glycol PEG precipitation. For separation of HMWI such as dsDNA and aggregates CaCl2 precipitation was the method of choice and PEG precipitation was used for mAbs capturing to separate LMWI, mainly HCP. Precipitation tests were performed with five different CHO cell culture supernatants and showed yields of at least 80 up to 95 %. Purity was roughly comparable to protein A purification. For further improvement of purity, a combination of caprylic acid and PEG precipitation was developed and showed equal values compared to protein A purification. For caprylic acid/PEG precipitation combination, a continuous operable lab scale precipitation reaction was designed and constructed. Different precipitation methods were combined, to replace the whole state of the art discontinuous mAb purification process with a continuous column free process. This combination consists of four different precipitations (CA, PEG, CaCl2 and CEP), aligned in a certain way to be able to drive the process continuously. Yield and purity of this process reach almost drugs substance values with a HCP concentration of 270 ppm, no HMWI and approximately 70 % yield. The implementation of an additional step (anion exchange filter of monolith) would lead to the achievement of equal purities compared to biopharmaceuticals. However, it was shown that there is the possibility to replace the state of the art column based mAbs purification with a novel continuous purification process, which has equal yield and purity with a far smaller economical footprint.