The presented study introduces a novel lipid based nanocarrier system, so called emulsomes, as a drug delivery platform facilitating the delivery of hydrophobic bioactive agents, whose medical use is otherwise limited. Curcumin, a poorly water soluble natural polyphenolic compound with intrinsic anti cancer properties was encapsulated in emulsomes. The new nanoformulation, named as CurcuEmulsomes, did not only overcome the bioavailability limitation of the compound and increase its solubility by 10,000 fold, but also exhibited promising therapeutic efficacy against HepG2 human carcinoma cell line in vitro. Further to achieve active delivery, CurcuEmulsomes were coated - for the first time - with crystalline bacterial cell surface layer (S-layer) fusion proteins with functional protein G domains. This allowed the nanocarrier to bind the human immunoglobulin (IgG) domains specifically, whereas no interaction was observed for those lacking these functional groups. Concisely, the promising in vitro efficacy of CurcuEmulsomes and the capability of S layer (fusion) technology to add functional surface characteristics to emulsomes highly featured the potential of S layer coated emulsomes for in vivo therapeutic applications.