Fish is an important protein source for the population of Burkina Faso. However, overfishing, fragmentation, loss of habitat, agriculture and other human pressures decline the fish populations diversity and biomass in the Burkinabe water bodies. Biological indices are essential for the assessment of water and ecosystem health and sustainable management to assure food security and healthy water bodies. The goal of this thesis is to characterize fish assemblages in the sampling area, to find out about human pressures on the fish community, to implement a fish, habitat and pressures database and to find species and metrics which react on pressures. The six sampling areas in the Nakambe catchment between the reservoir of Loumbila, North of Ouagadougou and the border of Ghana are exposed to pressure intensities. Altogether, 37 sites and 137 habitats were sampled. Each habitat was fished electrically and with a cast net. On site, adjacent landuse, stressors and physicochemical parameters were noted. With GIS, land use was refined, and migration barriers were identified. Most common families are Cichlidae and Cyprinidae, which together make out more than 50% of all caught individuals, whereas Anabantidae and Citharinidae are heavily endangered. The tested fish metrics react on the pressure intensity. This means, with increasing pressure, the fish stock decreases. Especially the relative abundance of Mormyridae show a distinct drop with the pressure intensity, while Cichlidae and Cyprinidae increase. Other authors (Hugueny et al. 1996; Anne, Lelek, and Tobias 1994) show the same trends. We also found some sentinel taxa like Auchenoglanis and Hydrocynus, which were only caught in low-pressure sites. This work is a basis for a fish based assessment method in Burkina Faso, which will be implemented by Burkinabe students in the frame of the SUSFISH project, helping managers to protect their waters in West Africa.