ABSTRACT Fires in forest areas have been considered an important threat to the Andean Region and the Amazon rainforest. On many occasions the occurrence of fire is human induced. In Colombia, fire is used to expand the agricultural frontier (including illicit crops) which results in the conversion of virgin forests for cattle ranching. Given the importance of avoiding deforestation and to control coca expansion, this research has two main objectives which are: 1) To understand the relationship between fires and deforestation, coca and deforestation and hence the relationship between coca and fires; 2) To examine the potential of using remotely sensed fires and socioeconomic variables (inhabitants in rural areas, basic unsatisfied needs and expulsion) to predict the occurrence of new coca fields in forest areas in Colombia. In addition, to build a model which uses relationships between coca increment, fires in the forest and socioeconomic variables. Coca increment is defined as part of this research as the sum of the increase in the area of coca cultivation between the subsequent and previous years calculated for each consecutive pair of years for the period 2000 - 2010, fires in the forest and socioeconomic variables. The analysis was assessed over a ten year period (2000-2010) at a municipality level in two areas with high coca dynamics (Central Region and Putumayo Caquetá) by means of Pearson correlations and three different models a Linear Probability model, a Logit model and a Probit model. The results of the analysis showed that there is a positive relationship between fire and deforestation. Although in general the correlation between coca and deforestation is positive, it differs at the municipality level depending upon the coca dynamics and the quantity of forest cover. The results of applying the Logit and Probit models showed that fire and expulsion can be used as indicators to highlight coca expansion in forest areas.